Presidente de la Sección de Neurocirugía Vascular y Terapia Endovascular de la SMCN.
Jefe de Neurociencias del Centro Médico Nacional 20 de Noviembre
Profesor de Terapia Endovascular Neurológica. Coordinador RESISSSTE Cerebro.
Fellow de Neurocirugía Vascular
Residente de Terapia Endovascular Neurológica
Fellow de Neurocirugía Vascular
Jorge Mura was born in Valdivia, Chile on December 24th, 1970. Attend the Medical School at the University of Chile in Santiago between 1988-1995. He made his internship in the Salvador Hospital and graduate cum laude. He made his residency at the Institute of Neurosurgery Alfonso Asenjo in Providencia, Santiago between 1995-1998 and graduate suma cum laude
He moved to São Paulo, Brazil the same year for a Clinical Fellowship in Cerebrovascular & Skull Base Surgery with the Professor Evandro de Oliveira team in the Institute of Neurological Sciences – Beneficencia Portuguesa Hospital between 1998-1999. Inmediately come back to the Institute Asenjo and co-create the Cerebrovascular Team.
He starts his academic career as Instructor of Neurosurgery in 1999. He creates in 2000 the first Fellowship Program in Cerebrovascular Surgery into the Department of Neurological Sciences of the University of Chile, in the year 2002 was incorporated the Skull Base Surgery Program and was created the Fellowship of CV & Skull Base Surgery at the Institute of Neurosurgery Asenjo, up-to-date 37 completed the 1 year program and 12 the 3-6 months abbreviated program; with neurosurgeons of Chile, Bolivia, Ecuador, Peru, Cuba, Argentina, Honduras, Venezuela, Spain and USA.
He is member of 14 national and international neurosurgical societies. He was director of the Chilean Society of Neurosurgery between 2005-2015. He was the coordinator of the Chilean Chapter of Microsurgical and Neurointerventional Cerebrovascular Surgery between 2005-2020, when he was elected as President of the Chilean Society of Neurosurgery period 2021-2023. He participates in the editorial comittee of the official journals of neurosurgery in Chile, Brazil and Argentina.
He gave more than 150 lectures about cerebrovascular and skull base surgery all around the world. He has more than 100 international publications, book chapters and peer-review comments. He has more than 175 presentations in national and international meetings in South America, México, USA and Europe. He has 15 awards in the Annual Chilean Congress of Neurosurgery and for 10 years awarded as the best presentation of the Congress.
His experience as a neurosurgeon is over 4,200 brain surgeries. His experience in cerebrovascular surgery is approximately 1,700 patients. He clipped 1,479 aneurysms. His experience in paraclinoid aneurysms is more than 460 cases up-to-date. He has performed more than 175 cerebral bypasses (low flow, high flow, EC-IC and IC-IC). He has experience in AVM is more than 150 cases. In skull base surgery he performed more than 750 complex skull base procedures: 400 Meningiomas of the cavernous Sinus, petroclival region, tubercullum sellae and other locations; more than 300 Schwannomas of the vestibular, trigeminal and low cranial nerves; Pituitary adenomas; Chondrosarcomas; etc. He performed more than 500 extradural anterior clinoidectomies, more than 200 middle fossa approaches and more than 100 transpetrous approaches.
His interest is mainly the teaching of his experience to the residents and cerebrovascular and skull base surgery fellows. He was appointed in 2019 as a Professor of Neurological Surgery at the Institute of Neurosurgery Asenjo for the University of Chile, a huge honor that was empty since 1987.
He was elected in October 2019 as the Vicepresident of the Chilean Society of Neurosurgery 2019-2021 and President for the period 2021-2023. In October 16th, 2020 was appointed as “Master of Chilean Neurosurgery”, the fourth in the Chilean Society of Neurosurgery history since its foundation in 1957. He was Secretary of the Vascular Chapter of the FLANC 2020-2022. He is Member of the Cerebrovascular Disease and Therapy Committee of the WFNS.
His research in the last years is oriented to minimally invasive and keyhole and key-exposure (MIPLATTA) complex cerebrovascular and skull base surgery and the improvement of the microsurgical techniques in the treatment of ruptured aneurysms and microsurgical management of SAH complications, and the comprehensive neurosurgical involvement into the management of the acute cerebral ischaemia.
Current Positions:
Education:
Research Interest:
Licenses & Certifications:
Selected Publications:
Cuello, J. P., Ortega-Gutierrez, S., Linares, G., Agarwal, S., Cunningham, A., Mohr, J. P., Mayer, S. A., Marshall, R. S., Claassen, J., Badjatia, N., Elkind, M. S. & Lee, K. (2014). Acute cervical myelopathy due to presumed fibrocartilaginous embolism: a case report and systematic review of the literature. Journal of spinal disorders & techniques 27 (8) E276-81. DOI: 10.1097/BSD.0000000000000115. PMID: 24901879.
Dr. Ivan Radovanovic MD, PhD, ISFM/FMH (CH) is an Associate Professor in the Department of Surgery (Division of Neurosurgery) at the University of Toronto. He holds the Baxter and Alma Ricard Chair in Neurosurgery and is a staff neurosurgeon at University Health Network specializing in cerebrovascular and skull base neurosurgery. He is also a senior scientist at the Krembil Brain Institute where he leads a basic and translational research program dedicated to understanding the development of vascular anomalies such as vascular malformations and cerebral aneurysms.
Dr. Radovanovic received a MD from the University of Geneva in 1998 and a PhD in molecular biology and genetics from the University of Zurich in 2003. He completed his neurosurgery residency in 2008 at the Geneva University Hospitals and fellowships in skull base surgery/neuro-oncology (2009) and cerebrovascular surgery (2010) at the Toronto Western Hospital. He then practiced as neurosurgery staff at the Geneva University Hospitals before being recruited back to University Health Network and the Krembil Brain Institute in 2013.
As a clinician, he has an interest and a large practice in minimally invasive approaches for vascular and skull base pathologies, in cerebral bypass surgery and in the multidisciplinary management of brain vascular malformations
As a scientist, he is interested in the genetic mechanisms and dysfunctions of developmental pathways underlying common and rare vascular lesions that are a significant cause of hemorrhagic stroke affecting a young population. Dr. Radovanovic’s group has identified somatic activating mutations in KRAS and subsequent downstream MAPK (MEK) signaling activation in brain arteriovenous malformations elucidating the genetic origin of this disease. These findings have been replicated by other groups and had a major impact on the field, opening avenues of small molecule targeted therapies of brain AVMs with MEK inhibitors.
Dr. Radovanovic current and future efforts include further study of the cerebral vasculature in health and disease with single cell RNA sequencing and other next generation genomics techniques as well as initiating clinical trials of clinically available MEK inhibitors for the treatment of extracranial and intracranial AVMs.
Dr. Radovanovic is a dedicated teacher of neurosurgical skills, he has trained numerous residents and >20 Canadian and international fellows in cerebrovascular and skull base techniques. He is also the director of the biannual Lougheed course in microneurosurgery at University of Toronto.
Dr. Radovanovic has published 100 peer reviewed papers, including in high impact journals such as the New England Journal of Medicine, Nature Reviews Neuroscience, Nature and others. He has extensively lectured nationally and
Dr. Rubino graduated from the National University of Tucumán in 1997. He completed his residency in neurosurgery at the Hospital Francés in Buenos Aires and continued his career as a neuroanatomy fellow at the Institute of Neurological Sciences of São Paulo under Dr. Evandro De Oliveira. He then continued as a fellow at the prestigious neuroanatomy laboratory at the University of Florida in Gainesville, under the late Prof. Albert L. Rhoton.
Dr. Rubino has participated in several research projects in cerebrovascular surgery, with works published in some of the main scientific journals in the specialty. In turn, he has been involved in numerous national and international academic and educational activities, including live surgery courses. He has contributed to several chapters in prestigious books in the specialty and has published «Vascular Neurosurgery», his book focused on the microsurgical treatment of vascular lesions of the brain. Dr. Rubino is a world-renowned specialist in cerebrovascular surgery and is a frequent speaker at the most important world congresses of the specialty.
Dr. Rubino is the Chair of Neurosurgey at the Hospital Alemán of Buenos Aires and Vice-chair of Neurosurgery and head of the Cerebrovascular Surgery section of the Hospital «El Cruce».
Dr. Rubino is a Member of the Argentine Association of Neurosurgery, and a member of the Argentine College of Neurosurgeons since 2009. He is an active member of several international scientific societies. He is a member of the editorial committee of the Argentine Journal of Neurosurgery and the Brazilian Journal of Neurosurgery.
Dr. Rubino focuses his research on the treatment of arteriovenous malformations, brain aneurysms, and brainstem cavernomas.
His areas of interest are brain tumors, microsurgery, anatomy and cerebrovascular and skull base surgery
Neurocirujano endovascular
Jefe de Servicio de Neuroradiología del Hospital Nacional de Pediatría JP Garrahan, Buenos Aires, Argentina.
Miembro titular de la Asociación Argentina de Neurocirugía del 2000.
Miembro del Colegio Argentino de Neurocirujanos desde el 2000.
Miembro Senior de la Federación Mundial de Neuroradiología Terapéutica e Intervencionista (WFITN) desde 2004.
Miembro Activo Senior de la Asociación Civil Colegio Argentino de Neurointervencionismo (ACCANI)
Trabajos publicados en revistas internacionales:
Abdalkader M. Pediatric Interventional Neuroradiology. Semin Neurol. 2023
Jun;43(3):408-418. doi: 10.1055/s-0043-1771511. Epub 2023 Aug 3. PMID: 37536373.
Andrade MG, Arcondo F, Armenteros C, Arroyo J, Beigelman R, Bonardo P, Bres
Bullrich M, Cabello C, Camargo G, Camerlingo S, Cárdenas R, Cháves H, Ciardi C,
Ciarrochi N, Cirio J, Claverie S, Colla Machado P, Costilla M, Díaz MF, Dossi D,
Gimenez ME, Giber F, Gómez Schneider M, González L, Hlavnika A, Ioli P, Isaac
CF, Izaguirre A, Klein F, Kuschner P, Lerman D, López R, Marquevich V, Miranda
JC, Murgieri M, Odzak A, Pahnke P, Persi G, Pizzorno J, Pollan J, Pujol Lereis
V, Requejo F, Robledo L, Rosales J, Rubin R, Sabio R, Tejada Jacob V, Tumino L,
Valdez P, Videtta W, Vilela A, Villaroel Saavedra V, Winkel M, Zurrú MC.
Consenso sobre accidente cerebrovascular isquémico agudo [Consensus on acute
ischemic stroke]. Medicina (B Aires). 2019;79 Suppl 2:1-46. Spanish. PMID:
31116699.
Guyon J, Álvarez H, Montes M, Daza Aramayo JM, Iturrieta P, Chaves H, Sarmiento
V, Tumino L, Domeniconi G, Castagna R, Sabio R, Videtta W, Ciarrocchi N, Lerman
D, Dossi DE, Balian NR, Rufino Saravia G, Alet MJ, Rodríguez Lucci F, Ciardi C,
Pujol Lereis V, Claverie S, Casanova M, González L, Mónaco JM, Cárdenas RE,
Cirio JJ, Arturi J, Requejo F, Plou PL, Orzuza G, Bonardo P, Díaz MF, Payaslian
S, Andrade MG, Gomez Schneider MM, Romano M, Colla Machado P, Arroyo J, Arcondo
MF, Svampa S, Armenteros C, Tejada Jacob V, Zurrú MC. Recomendaciones en el
Abordaje del Hematoma Intracerebral Espontáneo Durante la Internación
[Recommendations For The Management Of Spontaneous Intracerebral Hemorrhage
During Hospitalization]. Medicina (B Aires). 2022;82 Suppl 4:1-56. Spanish.
PMID: 36269297.
pediatric population. Childs Nerv Syst. 2016 Mar;32(3):505-9. doi:
10.1007/s00381-015-2992-z. Epub 2015 Dec 29. PMID: 26715300.
greyscale and Doppler ultrasound in initial evaluation and follow-up of
neurovascular malformations in children. Pediatr Radiol. 2024 Feb;54(2):347-356.
doi: 10.1007/s00247-023-05846-9. Epub 2024 Jan 9. Erratum in: Pediatr Radiol.
2024 Feb 1;: PMID: 38191809.
for neurointerventional procedures in infants. J Neurointerv Surg. 2022
Oct;14(10):973-975. doi: 10.1136/neurintsurg-2021-018092. Epub 2021 Oct 11.
PMID: 34635579.
in two pediatric patients: case reports. Childs Nerv Syst. 2022
Apr;38(4):789-794. doi: 10.1007/s00381-021-05181-0. Epub 2021 May 6. PMID:
33956211.
Chantada G, Francis JH, Abramson DH, Schaiquevich P. Pharmacokinetics of Orbital
Topotecan After Ophthalmic Artery Chemosurgery and Intravenous Infusion in the
Swine Model. Invest Ophthalmol Vis Sci. 2023 Sep 1;64(12):3. doi:
10.1167/iovs.64.12.3. PMID: 37656475; PMCID: PMC10479255.
Intracranial arteriovenous shunts in infants: A decade of experience from a
quaternary pediatric center. Interv Neuroradiol. 2023 Jun 18:15910199231180002.
doi: 10.1177/15910199231180002. Epub ahead of print. PMID: 37331964.
Perez V, Caixeta R, Neto JCA, Alarcón S, Silva S, Teixeira L, Antoneli CG,
Mattosinho C, Leal-Leal C, Castela G, Requejo F, Catala J, Macedo C, Chantada
the era of local ocular treatments: A consensus of the Grupo America Latina de
Oncologia Pediatrica (GALOP). Pediatr Blood Cancer. 2023 Jul;70(7):e30352. doi:
10.1002/pbc.30352. Epub 2023 Apr 14. PMID: 37057832.
Dural sinus malformation with giant pouch (DSMGP): symptoms and treatment.
Childs Nerv Syst. 2020 Feb;36(2):343-348. doi: 10.1007/s00381-019-04338-2. Epub
2019 Aug 8. PMID: 31396697.
Schaiquevich P. Topotecan Delivery to the Optic Nerve after Ophthalmic Artery
Chemosurgery. PLoS One. 2016 Mar 9;11(3):e0151343. doi:
10.1371/journal.pone.0151343. PMID: 26959658; PMCID: PMC4784825.
vascular malformations of the brain in pediatrics: Experience in a tertiary care
children’s hospital. Arch Argent Pediatr. 2021 Jun;119(3):152-161. English,
Spanish. doi: 10.5546/aap.2021.eng.152. PMID: 34033414.
dural arteriovenous fistula in a pediatric patient: positive outcome following
surgical treatment. Childs Nerv Syst. 2021 Jun;37(6):2063-2068. doi:
10.1007/s00381-020-04923-w. Epub 2020 Oct 27. PMID: 33108519.
Fandiño A, Schaiquevich P, Chantada G. Combined high-dose intra-arterial and
intrathecal chemotherapy for the treatment of a case of extraocular
retinoblastoma. Pediatr Blood Cancer. 2018 Dec;65(12):e27385. doi:
10.1002/pbc.27385. Epub 2018 Aug 13. PMID: 30105793.
superselective ophthalmic artery chemotherapy for retinoblastoma: The Garrahan
Hospital experience. Interv Neuroradiol. 2018 Feb;24(1):93-99. doi:
10.1177/1591019917738962. Epub 2017 Nov 9. PMID: 29119878; PMCID: PMC5772542.
to: Use of greyscale and Doppler ultrasound in initial evaluation and follow‑up
of neurovascular malformations in children. Pediatr Radiol. 2024 Apr;54(4):661.
doi: 10.1007/s00247-024-05868-x. Erratum for: Pediatr Radiol. 2024
Feb;54(2):347-356. PMID: 38300287.
Cerebral aneurysms in children: are we talking about a single pathological
entity? Childs Nerv Syst. 2010 Oct;26(10):1329-35. doi:
10.1007/s00381-010-1205-z. Epub 2010 Jul 13. PMID: 20625744.
pediatric population. Clinical features and treatment modalities. Childs Nerv
Syst. 2015 Sep;31(9):1509-14. doi: 10.1007/s00381-015-2778-3. Epub 2015 Jun 9.
PMID: 26054329.
Asprea M, Requejo F, Abramson DH, Bramuglia GF, Chantada GL. Pharmacokinetic
analysis of melphalan after superselective ophthalmic artery infusion in
preclinical models and retinoblastoma patients. Invest Ophthalmol Vis Sci. 2012
Jun 28;53(7):4205-12. doi: 10.1167/iovs.12-9501. PMID: 22628208.
Pagenstecher A, Nagursky H, Schumacher M. Liquid 2-poly-hydroxyethyl-
methacrylate embolization of experimental arteriovenous malformations:
feasibility study. AJNR Am J Neuroradiol. 2002 Mar;23(3):422-9. PMID: 11901012;
PMCID PMC7975285.
carotid artery, persistent proatlantal 1 artery and rete mirabile in a child
with 22q11 deletion syndrome. Childs Nerv Syst. 2018 Dec;34(12):2509-2513. doi:
10.1007/s00381-018-3910-y. Epub 2018 Jul 16. PMID: 30014308.
intracranial carotid artery during tumor removal with n-butyl-2-cyanoacrylate:
technical case report. Neurosurgery. 2006 Oct;59(4 Suppl 2):ONSE484-5;
discussion ONSE485. doi: 10.1227/01.NEU.0000232769.86686.96. PMID: 17041522.
pharyngitis internal carotid artery pseudoaneurysm with a covered stent in a
child: a case report. Childs Nerv Syst. 2013 Aug;29(8):1369-73. doi:
10.1007/s00381-013-2083-y. Epub 2013 Mar 27. PMID: 23532343.
Lipsich J, Schumacher M. Ophthalmic artery microcatheterization for research
purposes in pigs. A technical note. J Invest Surg. 2014 Oct;27(5):291-3. doi:
10.3109/08941939.2014.894599. Epub 2014 Mar 24. PMID: 24660750.
Libros publicados:
Premios:
Hospital Israelita “EZRAH” (Bs As – Argentina)
Hospital Escuela de Clínicas José de San Martín (Argenitna)
Instituto de Neurociencias Aplicadas de la Universidad de Buenos Aires (UBA)
Clínica Adventista Belgrano – Instituto FLENI (Bs As -Argentina)
Sociedad Ibero-Latinoamericana de Neurointervencionismo (SILAN)
Instituto ENERI.-Prof. Dr. Pedro Lylyk.
4to Congreso “Actualidades en el manejo de enfermedades cerebrovasculares”: Entrenamiento, Dominio y Evolución | ||
Horario | Ponencia | Profesor |
8:00 – 8:20 | REGISTRO | |
Módulo I | ||
8:20 – 8:35 | Infarto cerebral como problema de salud pública | Dra. Lilia Núñez Orozco |
8:35 – 8:50 | Trombolisis en infarto cerebral | Dr. Victor Hugo Gomez Arias |
8:50 – 9:05 | Estrategias de manejo en stroke por oclusión de vaso mediano | Dr. Enrique Castellanos Pedroza |
9:05 – 9:20 | Tratamiento microquirúrgico de aneurismas múltiples: recomendaciones y toma de decisiones | Dra. Karina Toledo Villa |
9:20 – 9:35 | Inauguración CAMEC 24 | Comité organizador y directivos |
9:35 – 9:55 | Tratamiento de aneurismas de cerebral media, experiencia y actualidades | Dr. Igor Toco Olivare |
9:55 – 10:10 | Experiencia en rescate vascular en stroke | Dr. Santiago Ortega Gutiérrez |
10:10 – 10:30 | Cerebral Revascularization in Acute Ischaemia | Prof. Jorge Mura |
10:30 – 10:40 | Preguntas y respuestas | Profesores del módulo |
10:30 – 10:45 | RECESO | |
Módulo II | ||
10:45 – 11:00 | Cirugía de base de cráneo y neurocirugía vascular | Dr. Diego Méndez Rosito |
11:00 – 11:15 | Abordaje unico para aneurismas cerebrales | Dr. Carlos Castillo Rangel |
11:15 – 11:35 | Endoscopía en patología aneurismática | Dr. Juan Luis Gomez Amador |
11:35 – 11:50 | Manejo endovascular de aneurismas rotos | Dr. Jairo Fernández |
11:50 – 12:05 | Key Points en Aneurismas Cerebrales Complejos | Dr. Arturo Muñoz Cobos |
12:05 – 12:20 | Experiencia en microcirugía de aneurismas de AcoA | Dr. Francisco López González |
12:20 – 12:35 | Tratamiento endovascular en aneurismas de ACA-AcoA | Dr. Vicente Garza O. |
12:35 – 12:55 | Evolution of minimally invasive aneurysm surgery | Dr. Ivan Radovanovic |
12:55 – 13:15 | Experiencia en manejo quirúrgico en aneurismas de circulación posterior | Prof. Pablo Rubino |
13:15 – 13:40 | Preguntas y Respuestas con Profesores del Modulo | |
Módulo III | ||
13:40 – 14:00 | Experiencia en manejo endovascular de retinoblastomas | Dr. Flavio Requejo |
14:00 – 14:15 | Tratamiento endovascular de aneurismas residuales | Dr. Jorge Arturo Santos Franco |
14:15 – 14:35 | Tratamiento de aneurismas con dispositivos avanzados | Dr. Jairo Fernández |
14:20 – 14:35 | Tips de penetrabilidad de EVO arterial y venoso en MAVs complejas | Dr. Gustavo Melo Guzmán |
14:50 – 15:10 | Malformación aneurismática de la Vena de Galeno | Dr. Flavio Requejo |
15:00 – 15:15 | Preguntas y respuestas | Profesores del módulo |
15:15 | Conclusiones y clausura | Comité Organizador |
4to Congreso “Actualidades en el manejo de enfermedades cerebrovasculares”: Entrenamiento, Dominio y Evolución | ||
Horario | Ponencia | Profesor |
Módulo IV | ||
8:00 – 8:15 | Abordajes supra e infratentoriales para cavernomas pontinos | Dr. Leonardo Serrato Avila |
8:15 – 8:30 | Radiocirugía en MAVs: Estado del arte | Dr. Gabriel Huerta Hernández |
8:30 – 8:45 | Territorio exclusivo de la microcirugía | Dr. Miguel Adolfo Abdo Toro |
8:45 – 9:00 | Cirugia Vascular, actualidad y futuro | Dr. Andres Jaime Aguirre |
9:00 – 9:20 | AVM development, genetics and potential for targeted therapies | Dr. Ivan Radovanovic |
9:20 – 9:40 | Anatomía aplicada a malformaciones arteriovenosas cerebrales | Prof. Pablo Rubino |
9:40 – 10:00 | Manejo endovascular de fístulas durales | Dr. Santiago Ortega Gutiérrez |
10:00 – 10:20 | AVM surgery: indications, techniques and results of the Toronto Western Hospital experience | Dr. Ivan Radovanovic |
10:20 – 10:30 | Preguntas y respuestas | Profesores del módulo |
10:30 – 10:40 | RECESO | |
Módulo V | ||
10:40 – 10:55 | Diagnostico y rehabilitacion neuropsicologica en pacientes con stroke | Dra. Lucia Ledezma |
10:55 – 11:10 | RESISSSTE Cerebro | Dr. Juan Carlos Luján Guerra |
11:10 – 11:25 | Actualidades en manejo de enfermedad carotídea | Dr. Felipe Padilla |
11:25 – 11:40 | Oclusión en tandem | Dr. Luis Alberto Ordóñez Solorio |
11:40 – 11:55 | Trombectomia mecanica en ventana extendida | Dr. Victor Hugo Escobar De La Garma |
11:55 – 12:10 | Preguntas y respuestas | Profesores del módulo |
12:10 – 12:25 | RECESO | |
Módulo VI | ||
12:25 – 12:40 | Actualidades en tratamiento de malformaciones cavernosas | Dr. Ehcatl Castillo |
12:40 – 13:00 | Extradural Minipretemporal Approach MIPLATTA for Vascular Lesions of the Posterior Fossa | Prof. Jorge Mura |
13:00 – 13:15 | Decisiones de tratamiento en aneurismas de bifurcación | Dr. Juan José Ramírez Andrade |
13:15 – 13:30 | Cirugía en malformaciones cavernosas profundas y de tallo cerebral | Dr. Rabindranath García |
13:30 – 13:50 | Aneurismas Desafiantes | Prof. Pablo Rubino |
13:50 – 14:05 | Neurocirugia Hibrida en Aneurismas complejos | Dr. Juan Carlos Luján Guerra |
14:05 – 14:15 | Preguntas y respuestas | Profesores del módulo |
14:15 | Conclusiones y clausura | Comité Organizador |